Transfusion Management of Patients with IgA Deficiency and Anti-IgA during Liver Transplantation

Transfusion management of patients with IgA deficiency and anti-IgA during liver transplantation.

Severe anaphylactic or allergic reactions may occur during blood transfusion to patients who are IgA-deficient and have anti-IgA in their blood, particularly those with class-specific antibodies. These patients are a particular challenge to the hospital transfusion service when large volumes of blood components are required for transfusion support, as in liver transplantation. We have successfu...

IgA deficiency: implications for transfusion.

Anaphylactic transfusion reactions are acute, potentially life-threatening events with generalized signs and symptoms. Usually IgE mediated they may also result from antigen -antibody reaction involving non-IgE antibodies which fix complement and generate anaphylatoxins. The best documented reactions of the latter type result from presence of anti IgA antibodies in IgA deficient patients who re...

Syndrome with IgA Deficiency

Autosomal deletion syndromes are of great interest since measurable loss of genetic material could lead to the mapping of the human autosomes. Short arm deletions and long arm deletions of chromosome 18 have been described in association with phenotypic changes (Grouchy et al., 1963, 1964) and reviewed recently by Wolf et al. (1967) and Reinwein, Ritter, and Wolf (1967). Since a ring chromosome...

Autoimmunity in patients with selective IgA deficiency.

BACKGROUND AND OBJECTIVE Selective immunoglobulin A deficiency (SIgAD) is the most common primary antibody deticiency. Patients with SIgAD have a greater risk of concomitant autoimmune disorders than healthy individuals. The exact mechanism underlying the relationship between autoimmunity and SIgAD is not fully understood. The aim of this study was to evaluate potential associations between aut...

Spondyloarthropathies and IgA deficiency.